Assassin's Creed: Brotherhood of Venice is a co-operative tactical board game of infiltration and assassination. Set in Renaissance Venice at a time when the Brotherhood of Assassins expands in Italy, the game gives 1 to 4 players control of never seen before assassins in a campaign to develop their headquarters and advance the Brotherhood's agenda against the Templars.

Players must find the right balance between stealth and combat to progress through a mission-based campaign, developing their own abilities as well as their new headquarters.