Spider-Woman is back, and she's pulling no punches! Jessica Drew hasn't been feeling like herself lately. When the angry, irritable and unwell Spider-Woman takes a simple security gig to help her get back on her feet, she finds herself besieged by unknown forces out to destroy everything around her. But what does Jessica's illness have to do with the daughter of her old nemesis, Otto Vermis? Finding out will take Spider-Woman back to where it all began - Wundagore Mountain, the nightmarish place that gave her powers - and on a road trip to outer space with her BFF, Captain Marvel! But who is making Jess relive her traumas? And just how far will she go to secure a cure for what ails her? Plus: How will Spider-Woman be affected by Knull's symbiote invasion and the Kingpin's war on vigilantes? Collecting SPIDER-WOMAN (2020) #1-21.