In Mutants, 1-4 players mix and match genetics to create the ultimate warriors and demonstrate their prowess in the arena. By dominating the arena and freezing the most valuable mutants, you gain Victory Points - and whoever gets most of them wins.

The game is also has a solo mode called Uprising. You win Uprising if you defeat epic and unique bosses. Instead of racing to Victory Points, you will try to whittle down the health of your opposing boss!

2313 AD, thanks to the progress of genetics, making can create mutants to fight as genetic gladiators in bloody arena battles. Only humans with psychic abilities can control and lead them to victory. These "Psy Captains" all share one ultimate goal: to win the most prestigious and dangerous competition in the galaxy, the Mutants World Tournament!

In each round, players take turns until all players have used every card in their hand. At the end of the round, the player whose token is closest to the top space of the arena track scores Victory Points based on the round track. The game proceeds in this way for five rounds, after which players reveal their archives and gain additional prestige based on the freeze value of the mutants they have placed there.