After the 52nd Infantry Regiment's activation in 1917, the regiment was assigned to the Sixth Infantry Division. The Sixth Division was organized in November 1917 as a square division consisting of the 51st, 52nd, 53rd, and the 54th Infantry Regiments, the 16th, 17th and 18th Machine-Gun Battalions and the 3rd, 11th and 78th Field Artillery Regiments. The units of the division gathered in New York and left for France in July 1918. After marching and training all over western France, the Sixth was assigned on 31 August to the Vosges sector. There, a chain of lofty wooded peaks had stalemated both the French and German armies. Their mission was the defense of a 21-mile front. The division engaged in active patrols in no man's land and behind the German lines. In addition, infantry platoon strongpoints defended against German raiding parties which launched their attacks using liquid fire and grenades.