Jarrow Formulas SAMe 200 provides a full 200 mg SAMe (net yield) from 400 mg of SAMe tosylate disulfate. SAMe 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

With More of the Biologically Active S,S than R,S Form
Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made by microbiological fermentation and then processed without chemical solvents to preserve 68-80% (S,S) SAMe.

SAMe supports:

Brain Metabolism and Mood*
SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes.* It has also been proposed to be involved
in the formation or metabolism of neurotransmitters, which helps to
support a balanced mood.*

Joint Health*
SAMe supports the production of healthy connective tissue through transulfuration.* In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage.*

Liver Function*
SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.*

Jarrow Formulas SAMe 200 is foil blister-packed to maximize stability and provides 200 mg S-Adenosyl Methionine derived from 400 mg of SAMe Tosylate Disulfate.