Will these interfere with my jack points?

No. These skirts bolt to factory mounting locations and do not extend over or block access to factory jack points. You'll still be able to use a floor jack in the standard locations.

Do these require bolts and hardware?

You will need bolts to secure them to the factory mounting points. The skirts themselves do not include fasteners, so source hardware appropriate for your body panels.

How much ground clearance will I lose?

These skirts add minimal clearance loss since they follow the factory body line closely. Ground clearance change is negligible for street driving, though approach angle on steep driveways may change slightly depending on how low your suspension sits.